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KMID : 1144320120440050399
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감염과 화학요법
2012 Volume.44 No. 5 p.399 ~ p.402
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The First Case of Abacavir Hypersensitivity Associated with the HLA-B*57:01-Positive Allele in Korea
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Yoon Ji-Hyun
Kim Min-goo
Jin Sung-Joon
Kim Seung-Kyu
Lee Seo-Hee
Cheon Jae-Young
Yun Gi-Young
Kim Min-Kyung
Ha Ji-Yoon
Song Young-Goo
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Abstract
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On the 12th day of abacavir treatment, a 39-year old HIV-infected male patient was admitted with fever, generalized rash, abdominal pain, and watery diarrhea that had persisted for five days. Results of blood tests indicated rapid progression of hepatitis and renal failure. The day after stopping anti-retroviral therapy, his fever subsided and his liver function began to normalize. He was clinically diagnosed with abacavir hypersensitivity and was found to carry the HLA-B*57:01 allele. This is the first reported case of abacavir hypersensitivity associated with the presence of the HLA-B*57:01 allele in Korea.
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KEYWORD
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Abacavir, hypersensitivity, HLA-B*57:01, Korea
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